Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models
نویسندگان
چکیده
منابع مشابه
Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.
The antitumor activity of the methylating agent temozolomide has been evaluated against a panel of 17 xenografts derived from pediatric solid tumors. Temozolomide was administered p.o. daily for five consecutive days at a dose level of 66 mg/kg. Courses of treatment were repeated every 21 days for three cycles. Tumor lines were classified as having high, intermediate, or low sensitivity, determ...
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Global metabolomics analysis has the potential to uncover novel metabolic pathways that are differentially regulated during carcinogenesis, aiding in biomarker discovery for early diagnosis and remission monitoring. Metabolomics studies with human samples can be problematic due to high inter-individual variation; however xenografts of human cancers in mice offer a well-controlled model system. ...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2007
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.6.6.4096